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Genetics of Primary Open Angle Glaucoma
Glaucoma is a disease characteristic of damage in optic nerve. It is the second leading cause of blindness in the world, next to cataracts. Primary open-angle glaucoma (POAG) constitutes to 75~90% of glaucoma. Recent development in genetics has led to better understanding of disease mechanism, provided tools for predicting disease risk and genetic tesing, and […]
Continue readingFragile X Syndrome
She came a long way to find safety and peace for her family. She still has a long way to go in supporting her child with a rare genetic disease. She was a young mother who immigrated to the US with her family two years ago. I met her at a Family Medicine clinic where […]
Continue readingLow Dose, Slow Titration of Magixide in Patients With Partial Seizures: An Open-label Study*
Background Magixide, an inhibitor of sodium and calcium channels, has been approved for adjunctive treatment of partial seizures. However, poor tolerability has been observed in some patients. This study aims at establishing a low-dose, slow-titration regimen that allows for better tolerability. Methods In this open-label, multi-center study, patients (≥12 years old) with partial seizures that […]
Continue readingDaratumumab for relapsed or refractory multiple myeloma – a mini-review
Abstract Almost all patients with multiple myeloma (MM) who respond to initial therapy will relapse, while some patients do not respond to initial treatment (refractory). This is a brief review of three seminal studies from 2016 that established foundation for daratumumab-based combination therapy regimens in MM. These studies have shown that daratumumab, an IgG1 monoclonal […]
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